Demand for drugs is increasing impotence. And the desire to re «vospryat» not discouraged, even then, that after taking the pill can not be in the embrace of the beloved, and a white faience with uncontrollable diarrhea. However, the possible options.
«Drugs that help solve problems with erection, - said the doctor-sexologist Yuriy Prokopenko - not to incite or exacerbate the sensitivity of erogenous zones. They are the inflow of blood to the penis, and this contributes to the emergence or strengthening of erection ».
However, the rapid filling of blood can play and malevolent joke: after taking Viagra, men sometimes complain about the changes in vision, loss of color, flush to the face, eyes, headache, dizziness, trembling fingers, etc.
A side effect occurs simultaneously with the desired, and there really have to choose, most importantly. If a partner has become a black and white, you can turn off the light, as if Breaks diarrhea, holiday probably will have to move.
Sometimes, the men swear fakes. Tablets drunk, half-hour wait, and the effect of zero. Swindled! In fact, it is impossible to eat the medicine, fall flop on the sofa to watch a football match, and after a half hour enter victoriously into the bedroom. The drugs work only on the vascular level and without mental excitation not work.
Viagra blue pills with a substance «sildenafil», which in 1998 turned the world of sexual relations, were also not without sin. «In addition to headaches, high tide of blood-to-face, digestive disorders, cases of diarrhea and linen cloths before your eyes - said the chief of the National Center for Human Reproduction Michael Koryakin - it turned out that sildenafil inhibits the work of specific human proteins - mainly fosfodiesterazy-5 - which just need to monitor the occurrence of side effects from the pill.
As a result, the life parted a few dozen people who suffer from hypertension, cardiovascular disease, taking nitroglycerine or other means ».
And we can hardly begrudge the fact that their death occurred at the bed of love. Therefore, before you swallow stimulant, at least consult with the district doctor.
Finally, one of the most unpleasant side-effects of a variety of techniques for enhancing erection - this is priapizm. That is, the state of standing, when the favorite, after the night of love at work is going, but you forgive does not latch the fly.
Remember, gentlemen, men, is nothing to be proud of. If your erection lasts longer than 4-6 hours, then dial the number of urgent aid, or directly without pants get to the hospital. Otherwise, your precious body will cease to receive nutrients, oxygen, and high blood pressure starts to destroy its delicate structure, which can lead to impotence, and amputations to ...
The most ironic that the cause of erection problems often do not have to look in trousers, but in the head. And it does not deal with the help of pills, and having learned seduce a woman getting pleasure from the process. You may have to turn to a counselor, but it is worth it. I mean, is ...
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Tuesday, March 17, 2009
Sunday, March 15, 2009
Cialis Strips
Today, approximately 150 million men worldwide have problems with erection. According to experts, the use of Cialis Stripsa help them cope with this problem and establish a normal sexual life. Undoubtedly, the emergence of new highly effective drugs have led many men to start treatment.
Cialis Strips is already well proven itself in Europe, Australia and New Zealand. The first countries where the drug has become the United Kingdom, Denmark, Finland, Sweden and Germany.
Length effect Cialis Stripsa - more than a day - a unique opportunity to treat erectile dysfunction, allowing men to the violation to normalize their sexual life "- said Richard Pilnik (Richard Pilnik), President of the European division Eli Lilly.
"For many of the 31 million men in Europe, suffering from erectile dysfunction, Cialis Strips will fundamentally solve the problem" - says Paul Clark (Paul Clark), acting director of ICOS.
Cialis Strips is intended for the treatment of erectile dysfunction of any degree of seriousness. It is recommended to use the interior in a dose of 20 mg before the alleged sexual activity, regardless of the concomitant ingestion of food or alcohol.
Cialis Strips is a class of enzyme inhibitors fosfodiesterazy-5. Its operation is based on a selective and effective blockade fosfodiesterazy-5, which contributes to relax smooth muscle cells and increase blood flow to the penis.
Currently Cialis Strips - the only inhibitor fosfodiesterazy-5, the effect of which persists more than a day - up to 36 hours. It is important to note that the erection occurs only when sexual initiation. This will help couples do not plan their sexual relationships and not to abandon the normal rhythm of life. Having taken the drug the morning, take advantage of its effect can be at night.
As with all drugs of this class, categorical contraindication for Cialis Stripsa is its use in conjunction with nitrates, used in the treatment of cardiovascular diseases.
To date, more than 4000 men have participated in more than 60 clinical studies have proven the effectiveness and safety of the drug. Cialis Strips improved erectile function in 81% of men and showed good portability.
April 9 at the Russian Academy of Sciences held a scientific symposium «Cialis Strips (tadalafil) - a new tool for the treatment of erectile dysfunction» which came more than 500 medical specialists - urologists, cardiologists and Sexologists.
Russian doctors have been the results of 5 clinical studies Cialis Stripsa. It was attended by 1 112 men aged 22 to 82 years with erectile dysfunction of varying degrees of severity. The drug showed high efficacy in patients of all ages.
Studies have shown that the Cialis Stripsa does not depend on alcohol and nourishing dinner, no doubt, for the Russian men it will be another argument in favor of the drug. However, it should be noted, alcohol in large doses, by itself adversely affect the erection, and in addition, alcohol can cause erectile dysfunction.
Where to buy ed drugs?
Cialis Strips is already well proven itself in Europe, Australia and New Zealand. The first countries where the drug has become the United Kingdom, Denmark, Finland, Sweden and Germany.
Length effect Cialis Stripsa - more than a day - a unique opportunity to treat erectile dysfunction, allowing men to the violation to normalize their sexual life "- said Richard Pilnik (Richard Pilnik), President of the European division Eli Lilly.
"For many of the 31 million men in Europe, suffering from erectile dysfunction, Cialis Strips will fundamentally solve the problem" - says Paul Clark (Paul Clark), acting director of ICOS.
Cialis Strips is intended for the treatment of erectile dysfunction of any degree of seriousness. It is recommended to use the interior in a dose of 20 mg before the alleged sexual activity, regardless of the concomitant ingestion of food or alcohol.
Cialis Strips is a class of enzyme inhibitors fosfodiesterazy-5. Its operation is based on a selective and effective blockade fosfodiesterazy-5, which contributes to relax smooth muscle cells and increase blood flow to the penis.
Currently Cialis Strips - the only inhibitor fosfodiesterazy-5, the effect of which persists more than a day - up to 36 hours. It is important to note that the erection occurs only when sexual initiation. This will help couples do not plan their sexual relationships and not to abandon the normal rhythm of life. Having taken the drug the morning, take advantage of its effect can be at night.
As with all drugs of this class, categorical contraindication for Cialis Stripsa is its use in conjunction with nitrates, used in the treatment of cardiovascular diseases.
To date, more than 4000 men have participated in more than 60 clinical studies have proven the effectiveness and safety of the drug. Cialis Strips improved erectile function in 81% of men and showed good portability.
April 9 at the Russian Academy of Sciences held a scientific symposium «Cialis Strips (tadalafil) - a new tool for the treatment of erectile dysfunction» which came more than 500 medical specialists - urologists, cardiologists and Sexologists.
Russian doctors have been the results of 5 clinical studies Cialis Stripsa. It was attended by 1 112 men aged 22 to 82 years with erectile dysfunction of varying degrees of severity. The drug showed high efficacy in patients of all ages.
Studies have shown that the Cialis Stripsa does not depend on alcohol and nourishing dinner, no doubt, for the Russian men it will be another argument in favor of the drug. However, it should be noted, alcohol in large doses, by itself adversely affect the erection, and in addition, alcohol can cause erectile dysfunction.
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Monday, March 9, 2009
Where buy Cialis Strpis Online?
Cialis strips strips are available in the USA:
You can buy cialis strips online no recipe now. Countries that have stripes strips Cialis (tadalafil) (more than 40 countries): There is now Germany, Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Netherlands, Spain, Sweden, United Kingdom, New Zealand, Australia, Singapore, Saudi Arabia, South Africa, Mexico, Hong Kong and Canada.
This site is intended for those interested in the Cialis. We are here to share stories about ED (erectile dysfunction) and learn more about Cialis strips.
General information on strips Cialis ®
Cialis strips
What is the band strips Cialis (tadalafil)?
Cialis strips on the strip this class of drugs known as PDE-5 inhibitor, which is used to treat cases of male impotence. Elli Lilly and ICOS is currently marketing Cialis in the strips of tape in the U.S., UK, EU and the countries around the world.
How to strip bars Cialis (tadalafil) work?
Stripes stripes Cialis has the same effect as Viagra by blocking the enzyme called phosphodiesterase-5, or PDE-5. Stripes stripes Cialis is more specific than Viagra, which leads to a reduction in side effects and low doses. Stripes stripes Cialis helps smooth muscles in the penis relax and widen, allowing more blood to enter. As a result, you get faster installations and easier with Cialis strips.
How to strip bars cialis strips (tadalafil) work?
Stripes stripes Cialis approved for the market approved for the treatment of mild to severe ED of 10 and 20 mg dose of Cialis lane stripes. Andalusia buy Cialis strips, labels for each of these markets means that the product should be taken prior to anticipated sexual activity and without regard to food. Like Viagra, sexual stimulation is needed for Cialis to work the band band. According to the label, the effectiveness of strip strip Cialis may persist up to 24 hours after the pills are taken. In Australia and the USA, the label indicates efficacy up to 36 hours after departure.
Who could not use the strips Cialis?
Stripes stripes Cialis is not for everyone. Men taking any form of nitrates (often used to control anginal chest pain) should never take Cialis strips, because the combination can lead to a dangerous reduction in blood pressure. Men taking medicines called "alpha blockers" (sometimes prescribed for prostate problems or high blood pressure), with the exception of Flomax ® (tamsulosin HCl) 0,4 mg once daily, should not take Cialis strips. This side effect of this combination can cause a significant decrease in blood pressure.
For more information about Cialis strips strips - and see how it compares with Viagra and Levitra
Stripes stripes Cialis can cause low blood pressure suddenly dangerous level, if other drugs. You can get dizzy, faint, or heart attack or stroke.
Do not take Cialis lane stripes, if you:
Taking medicines called nitrates.
use recreational drugs called "poppers" like amyl nitrite and butyl nitrite.
Tell all medical institutions, you are taking Cialis strips. If you need emergency medical care for the heart problem, it is important that your doctor know, last time I took Cialis strips.
After taking one tablet, some of the active ingredient in Cialis strips strip remains in the body for more than 2 days. The active substance can remain longer if you have any problems with the kidneys or liver, or take other medications.
What is Cialis strips?
Stripes stripes Cialis is an oral drug for the treatment of erectile dysfunction (ED) in men. ED is a condition where the penis does not harden and expand when a man is sexually excited, or you can not maintain erection. The man who has problems getting or maintaining erection should see his doctor for help if the condition prevents it. Cialis may help a man with strips strips ED get and retain the building in the sexually aroused.
Who should not take Cialis strips?
Cialis Strips available in the U.S.:
You can buy Cialis Strips Now by prescription. Countries that have Cialis Strips (tadalafil)(more than 40 countries): Available now in Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Netherlands, Spain, Sweden, United Kingdom, New Zealand, Australia, Singapore, Saudi Arabia, South Africa, Mexico, Hong Kong, and Canada.
This site is for the person who is interested in Cialis Strips . We are here to share stories about ED (erectile dysfunction) and to learn more about Cialis Strips .
General Information about Cialis Strips ®
Cialis Strips
What is Cialis Strips (tadalafil)?
Cialis Strips is in a class of medications known as PDE-5 inhibitors, which are used to treat cases of male impotence. Elli Lilly and Icos are currently marketing Cialis Strips in the U.S., UK, EU , and countries around the world.
How does Cialis Strips (tadalafil) work?
Cialis Strips acts in the same way as Viagra, by blocking an enzyme called phosphodiesterase-5, or PDE-5. Cialis Strips is more targeted than Viagra which results in fewer sides effects and lower dosage. Cialis Strips helps the smooth muscles in the penis relax and widen, which allows for more blood to enter. As a result, you gain erections faster and easier with Cialis Strips .
How well does Cialis Strips (tadalafil) work?
Cialis Strips is approved in authorized markets for the treatment of mild to severe ED at both 10 and 20 mg Cialis Strips doses. When you buy Cialis Strips , the labels in each of these markets indicate that the product should be taken prior to anticipated sexual activity and without regard to food. Just like Viagra, sexual stimulation is needed for Cialis Strips to work. According to the European label, the efficacy of Cialis Strips may persist up to 24 hours after the pill is taken. In Australia and United States the label indicates efficacy up to 36 hours after dosing.
Who can not use Cialis Strips ?
Cialis Strips is not for everyone. Men taking any form of nitrates (often used to control anginal chest pain) should never take Cialis Strips , as the combination may cause an unsafe drop in blood pressure. Men taking medicines called "alpha blockers" (sometimes prescribed for prostate problems or high blood pressure), with exception of Flomax® (tamsulosin HCl) 0.4 mg once-daily, should not take Cialis Strips . This side effects from this combination could cause a significant drop in blood pressure.
learn more about Cialis Strips - and see how it compares to Levitra and Viagra
Cialis Strips can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. You could get dizzy, faint, or have a heart attack or stroke.
Do NOT take Cialis Strips if you:
take any medicines called nitrates.
use recreational drugs called "poppers" like amyl nitrite and butyl nitrite.
Tell all your healthcare providers that you take Cialis Strips . If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took Cialis Strips .
After taking a single tablet, some of the active ingredient of Cialis Strips remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.
What is Cialis Strips ?
Cialis Strips is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men. ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has trouble getting or keeping an erection should see his doctor for help if the condition bothers him. Cialis Strips may help a man with ED get and keep an erection when he is sexually excited.
Who should not take Cialis Strips ?
Do not take Cialis Strips if you:
take any medicines called nitrates. Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm. Medicines called nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Nitrates can also be found in other medicines such as isosorbidedinitrate or isosorbide mononitrate. Some recreational drugs called "poppers" also contain nitrates, such as amyl nitrite and butyl nitrite. Do not use Cialis Strips if you are using these drugs. Ask your doctor or pharmacist if you are not sure if any of your medicines are nitrates.
you have been told by your healthcare provider to not have sexual activity because of health problems. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease.
are allergic to Cialis Strips or any of its ingredients. The active ingredient in Cialis Strips is called tadalafil. See the end of this leaflet for a complete list of ingredients.
What should you discuss with your doctor before taking Cialis Strips ?
Before taking Cialis Strips , tell your doctor about all your medical problems, including if you:
have heart problems such as angina, heart failure, irregular heartbeats, or have had a heart attack. Ask your doctor if it is safe for you to have sexual activity.
have low blood pressure or have high blood pressure that is not controlled
have had a stroke
have liver problems
have kidney problems or require dialysis
have retinitis pigmentosa, a rare genetic (runs in families) eye disease
have stomach ulcers
have a bleeding problem
have a deformed penis shape or Peyronie's disease
have had an erection that lasted more than 4 hours
have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia
Can other medications affect Cialis Strips ?
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Cialis Strips and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take any of the following:*
medicines called nitrates.
medicines called alpha blockers. These include Hytrin® (terazosin HCl), Flomax® (tamsulosin HCl), Cardura® (doxazosin mesylate), Minipress® (prazosin HCl) or Uroxatral® (alfuzosin HCl). Alpha blockers are sometimes prescribed for prostate problems or high blood pressure. If Cialis Strips is taken with certain alpha blockers, your blood pressure could suddenly drop. You could get dizzy or faint.
ritonavir (Norvir®) or indinavir (Crixivan®)
ketoconazole or itraconazole (such as Nizoral® or Sporanox®)
erythromycin
other medicines or treatments for ED
How should you take Cialis Strips ?
Take Cialis Strips exactly as your doctor prescribes. Cialis Strips comes in different doses (5 mg, 10 mg, and 20 mg). For most men, the recommended starting dose is 10 mg. Cialis Strips should be taken no more than once a day. Some men can only take a low dose of Cialis Strips because of medical conditions or medicines they take. Your doctor will prescribe the dose that is right for you.
If you have kidney problems, your doctor may start you on a lower dose of Cialis Strips .
If you have kidney or liver problems or you are taking certain medications, your doctor may limit your highest dose of Cialis Strips to 10 mg and may also limit you to one tablet in 48 hours (2 days) or one tablet in 72 hours (3 days).
If you have prostate problems or high blood pressure for which you take medicines called alpha blockers, your doctor may start you on a lower dose of Cialis Strips .
Take one Cialis Strips tablet before sexual activity. In some patients, the ability to have sexual activity was improved at 30 minutes after taking Cialis Strips when compared to a sugar pill. The ability to have sexual activity was improved up to 36 hours after taking Cialis Strips when compared to a sugar pill. You and your doctor should consider this in deciding when you should take Cialis Strips prior to sexual activity. Some form of sexual stimulation is needed for an erection to happen with Cialis Strips . Cialis Strips may be taken with or without meals. Do not change your dose of Cialis Strips without talking to your doctor. Your doctor may lower your dose or raise your dose, depending on how your body reacts to Cialis Strips .
Do not drink alcohol to excess when taking Cialis Strips (for example, 5 glasses of wine or 5 shots of whiskey). When taken in excess, alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure. If you take too much Cialis Strips , call your doctor or emergency room right away.
What are the possible side effects of Cialis Strips ?
The most common side effects with Cialis Strips are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking Cialis Strips . Back pain and muscle aches usually go away by themselves within 48 hours. Call your doctor if you get a side effect that bothers you or one that will not go away.
Cialis Strips may uncommonly cause an erection that won't go away (priapism). If you get an erection that lasts more than 4 hours, get medical help right away. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections.
Cialis Strips may uncommonly cause vision changes, such as seeing a blue tinge to objects or having difficulty telling the difference between the colors blue and green.
In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including Cialis Strips ) reported a sudden decrease or loss of vision in one or both eyes. It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including Cialis Strips , and call a doctor right away.
General Information about Cialis Strips :
Medicines are sometimes prescribed for conditions other than those described in patient information leaflets. Do not use Cialis Strips for a condition for which it was not prescribed. Do not give Cialis Strips to other people, even if they have the same symptoms that you have. It may harm them.
You can buy cialis strips online no recipe now. Countries that have stripes strips Cialis (tadalafil) (more than 40 countries): There is now Germany, Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Netherlands, Spain, Sweden, United Kingdom, New Zealand, Australia, Singapore, Saudi Arabia, South Africa, Mexico, Hong Kong and Canada.
This site is intended for those interested in the Cialis. We are here to share stories about ED (erectile dysfunction) and learn more about Cialis strips.
General information on strips Cialis ®
Cialis strips
What is the band strips Cialis (tadalafil)?
Cialis strips on the strip this class of drugs known as PDE-5 inhibitor, which is used to treat cases of male impotence. Elli Lilly and ICOS is currently marketing Cialis in the strips of tape in the U.S., UK, EU and the countries around the world.
How to strip bars Cialis (tadalafil) work?
Stripes stripes Cialis has the same effect as Viagra by blocking the enzyme called phosphodiesterase-5, or PDE-5. Stripes stripes Cialis is more specific than Viagra, which leads to a reduction in side effects and low doses. Stripes stripes Cialis helps smooth muscles in the penis relax and widen, allowing more blood to enter. As a result, you get faster installations and easier with Cialis strips.
How to strip bars cialis strips (tadalafil) work?
Stripes stripes Cialis approved for the market approved for the treatment of mild to severe ED of 10 and 20 mg dose of Cialis lane stripes. Andalusia buy Cialis strips, labels for each of these markets means that the product should be taken prior to anticipated sexual activity and without regard to food. Like Viagra, sexual stimulation is needed for Cialis to work the band band. According to the label, the effectiveness of strip strip Cialis may persist up to 24 hours after the pills are taken. In Australia and the USA, the label indicates efficacy up to 36 hours after departure.
Who could not use the strips Cialis?
Stripes stripes Cialis is not for everyone. Men taking any form of nitrates (often used to control anginal chest pain) should never take Cialis strips, because the combination can lead to a dangerous reduction in blood pressure. Men taking medicines called "alpha blockers" (sometimes prescribed for prostate problems or high blood pressure), with the exception of Flomax ® (tamsulosin HCl) 0,4 mg once daily, should not take Cialis strips. This side effect of this combination can cause a significant decrease in blood pressure.
For more information about Cialis strips strips - and see how it compares with Viagra and Levitra
Stripes stripes Cialis can cause low blood pressure suddenly dangerous level, if other drugs. You can get dizzy, faint, or heart attack or stroke.
Do not take Cialis lane stripes, if you:
Taking medicines called nitrates.
use recreational drugs called "poppers" like amyl nitrite and butyl nitrite.
Tell all medical institutions, you are taking Cialis strips. If you need emergency medical care for the heart problem, it is important that your doctor know, last time I took Cialis strips.
After taking one tablet, some of the active ingredient in Cialis strips strip remains in the body for more than 2 days. The active substance can remain longer if you have any problems with the kidneys or liver, or take other medications.
What is Cialis strips?
Stripes stripes Cialis is an oral drug for the treatment of erectile dysfunction (ED) in men. ED is a condition where the penis does not harden and expand when a man is sexually excited, or you can not maintain erection. The man who has problems getting or maintaining erection should see his doctor for help if the condition prevents it. Cialis may help a man with strips strips ED get and retain the building in the sexually aroused.
Who should not take Cialis strips?
Cialis Strips available in the U.S.:
You can buy Cialis Strips Now by prescription. Countries that have Cialis Strips (tadalafil)(more than 40 countries): Available now in Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Netherlands, Spain, Sweden, United Kingdom, New Zealand, Australia, Singapore, Saudi Arabia, South Africa, Mexico, Hong Kong, and Canada.
This site is for the person who is interested in Cialis Strips . We are here to share stories about ED (erectile dysfunction) and to learn more about Cialis Strips .
General Information about Cialis Strips ®
Cialis Strips
What is Cialis Strips (tadalafil)?
Cialis Strips is in a class of medications known as PDE-5 inhibitors, which are used to treat cases of male impotence. Elli Lilly and Icos are currently marketing Cialis Strips in the U.S., UK, EU , and countries around the world.
How does Cialis Strips (tadalafil) work?
Cialis Strips acts in the same way as Viagra, by blocking an enzyme called phosphodiesterase-5, or PDE-5. Cialis Strips is more targeted than Viagra which results in fewer sides effects and lower dosage. Cialis Strips helps the smooth muscles in the penis relax and widen, which allows for more blood to enter. As a result, you gain erections faster and easier with Cialis Strips .
How well does Cialis Strips (tadalafil) work?
Cialis Strips is approved in authorized markets for the treatment of mild to severe ED at both 10 and 20 mg Cialis Strips doses. When you buy Cialis Strips , the labels in each of these markets indicate that the product should be taken prior to anticipated sexual activity and without regard to food. Just like Viagra, sexual stimulation is needed for Cialis Strips to work. According to the European label, the efficacy of Cialis Strips may persist up to 24 hours after the pill is taken. In Australia and United States the label indicates efficacy up to 36 hours after dosing.
Who can not use Cialis Strips ?
Cialis Strips is not for everyone. Men taking any form of nitrates (often used to control anginal chest pain) should never take Cialis Strips , as the combination may cause an unsafe drop in blood pressure. Men taking medicines called "alpha blockers" (sometimes prescribed for prostate problems or high blood pressure), with exception of Flomax® (tamsulosin HCl) 0.4 mg once-daily, should not take Cialis Strips . This side effects from this combination could cause a significant drop in blood pressure.
learn more about Cialis Strips - and see how it compares to Levitra and Viagra
Cialis Strips can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. You could get dizzy, faint, or have a heart attack or stroke.
Do NOT take Cialis Strips if you:
take any medicines called nitrates.
use recreational drugs called "poppers" like amyl nitrite and butyl nitrite.
Tell all your healthcare providers that you take Cialis Strips . If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took Cialis Strips .
After taking a single tablet, some of the active ingredient of Cialis Strips remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.
What is Cialis Strips ?
Cialis Strips is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men. ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has trouble getting or keeping an erection should see his doctor for help if the condition bothers him. Cialis Strips may help a man with ED get and keep an erection when he is sexually excited.
Who should not take Cialis Strips ?
Do not take Cialis Strips if you:
take any medicines called nitrates. Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm. Medicines called nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Nitrates can also be found in other medicines such as isosorbidedinitrate or isosorbide mononitrate. Some recreational drugs called "poppers" also contain nitrates, such as amyl nitrite and butyl nitrite. Do not use Cialis Strips if you are using these drugs. Ask your doctor or pharmacist if you are not sure if any of your medicines are nitrates.
you have been told by your healthcare provider to not have sexual activity because of health problems. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease.
are allergic to Cialis Strips or any of its ingredients. The active ingredient in Cialis Strips is called tadalafil. See the end of this leaflet for a complete list of ingredients.
What should you discuss with your doctor before taking Cialis Strips ?
Before taking Cialis Strips , tell your doctor about all your medical problems, including if you:
have heart problems such as angina, heart failure, irregular heartbeats, or have had a heart attack. Ask your doctor if it is safe for you to have sexual activity.
have low blood pressure or have high blood pressure that is not controlled
have had a stroke
have liver problems
have kidney problems or require dialysis
have retinitis pigmentosa, a rare genetic (runs in families) eye disease
have stomach ulcers
have a bleeding problem
have a deformed penis shape or Peyronie's disease
have had an erection that lasted more than 4 hours
have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia
Can other medications affect Cialis Strips ?
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Cialis Strips and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take any of the following:*
medicines called nitrates.
medicines called alpha blockers. These include Hytrin® (terazosin HCl), Flomax® (tamsulosin HCl), Cardura® (doxazosin mesylate), Minipress® (prazosin HCl) or Uroxatral® (alfuzosin HCl). Alpha blockers are sometimes prescribed for prostate problems or high blood pressure. If Cialis Strips is taken with certain alpha blockers, your blood pressure could suddenly drop. You could get dizzy or faint.
ritonavir (Norvir®) or indinavir (Crixivan®)
ketoconazole or itraconazole (such as Nizoral® or Sporanox®)
erythromycin
other medicines or treatments for ED
How should you take Cialis Strips ?
Take Cialis Strips exactly as your doctor prescribes. Cialis Strips comes in different doses (5 mg, 10 mg, and 20 mg). For most men, the recommended starting dose is 10 mg. Cialis Strips should be taken no more than once a day. Some men can only take a low dose of Cialis Strips because of medical conditions or medicines they take. Your doctor will prescribe the dose that is right for you.
If you have kidney problems, your doctor may start you on a lower dose of Cialis Strips .
If you have kidney or liver problems or you are taking certain medications, your doctor may limit your highest dose of Cialis Strips to 10 mg and may also limit you to one tablet in 48 hours (2 days) or one tablet in 72 hours (3 days).
If you have prostate problems or high blood pressure for which you take medicines called alpha blockers, your doctor may start you on a lower dose of Cialis Strips .
Take one Cialis Strips tablet before sexual activity. In some patients, the ability to have sexual activity was improved at 30 minutes after taking Cialis Strips when compared to a sugar pill. The ability to have sexual activity was improved up to 36 hours after taking Cialis Strips when compared to a sugar pill. You and your doctor should consider this in deciding when you should take Cialis Strips prior to sexual activity. Some form of sexual stimulation is needed for an erection to happen with Cialis Strips . Cialis Strips may be taken with or without meals. Do not change your dose of Cialis Strips without talking to your doctor. Your doctor may lower your dose or raise your dose, depending on how your body reacts to Cialis Strips .
Do not drink alcohol to excess when taking Cialis Strips (for example, 5 glasses of wine or 5 shots of whiskey). When taken in excess, alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure. If you take too much Cialis Strips , call your doctor or emergency room right away.
What are the possible side effects of Cialis Strips ?
The most common side effects with Cialis Strips are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking Cialis Strips . Back pain and muscle aches usually go away by themselves within 48 hours. Call your doctor if you get a side effect that bothers you or one that will not go away.
Cialis Strips may uncommonly cause an erection that won't go away (priapism). If you get an erection that lasts more than 4 hours, get medical help right away. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections.
Cialis Strips may uncommonly cause vision changes, such as seeing a blue tinge to objects or having difficulty telling the difference between the colors blue and green.
In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including Cialis Strips ) reported a sudden decrease or loss of vision in one or both eyes. It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including Cialis Strips , and call a doctor right away.
General Information about Cialis Strips :
Medicines are sometimes prescribed for conditions other than those described in patient information leaflets. Do not use Cialis Strips for a condition for which it was not prescribed. Do not give Cialis Strips to other people, even if they have the same symptoms that you have. It may harm them.
Wednesday, March 4, 2009
Description Cialis Strips
Cialis Strips
Cialis Strips - medicines to treat erectile dysfunction (Erectile Dysfunction). This is the relaxation of penile arteries and increases blood flow to the penile tissues, and resulting in an erection.
Latin name:
Cialis Strips / Cialis.
The composition and manner of publication:
Cialis Strips coated tablets, 1, 2, 4 or 8 pieces. in the package.
1 tablet contains 20 mg tadalafil Cialis Strips.
Active-active agent:
Tadalafil / Tadalafil.
Properties / Action:
Cialis Strips (tadalafil) is an effective, reversible, selective inhibitor of certain fosfodiesterazy type 5 (FDE5) guanozin cyclic monophosphate (tsGMF). When sexual excitation causes local release of nitric oxide, inhibition FDE5 tadalafilom leads to higher levels tsGMF in the corpus cavernosum of the penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis causing an erection. Tadalafil has no effect in the absence of sexual stimulation.
In vitro studies have shown that tadalafil is a selective inhibitor FDE5. FDE5 an enzyme that is found in smooth muscles of cavernous bodies in vascular smooth muscles of internal organs, skeletal muscle, platelets, kidney, lung, and cerebellum. Step FDE5 to tadalafil is more active than the other fosfodiesterazy. Tadalafil is 10 000 times more potent against FDE5 that FDE1, FDE2 and FDE4, which located in the heart, brain, blood vessels, liver and other organs. Tadalafil 10 000 times more blocks FDE5 that FDE3 - enzyme which is located in the heart and blood vessels. This selectivity in comparison with FDE5 against Fdez Fdez is important because an enzyme involved in the reduction of the heart muscle. In addition, tadalafil approximately 700 times more active against FDE5 that FDE6 found in the retina and is responsible for fotoperedachu. Tadalafil is 10 000 times more potent against FDE5 compared with its impact on FDE7 - FDE10.
Tadalafil improves erection and the possibility of a satisfying sexual relationship. The drug is valid for 36 hours. The effect is manifested after 16 minutes after taking the drug in the presence of sexual arousal.
Tadalafil in healthy individuals is a reliable change systolic and diastolic pressures compared with placebo in the prone position (mean maximum decrease of 1, 6 / 0, 8 mm Hg. Art, respectively) and standing (maximum mean decrease of 0 , 2 / 4, 6 mm Hg. art., respectively). Tadalafil does not cause a reliable change in heart rate.
Tadalafil does not cause changes in the recognition of colors (blue / green), due to its low affinity FDEb. In addition, tadalafil no influence on visual acuity, elektroretinogrammu, intraocular pressure and pupil size.
Tadalafil study in men in a daily dose of 10 mg showed no clinically significant effect on the quantity of drugs and sperm concentration, motility and morphology of spermatozoa.
Pharmacokinetics:
After receiving tadalafil Cialis Stripsa interior absorbs quickly. The average maximum concentration (smax) in plasma is reached after an average of 2 hours after ingestion.
The rate and extent of tadalafil absorption is not dependent on food intake, so Cialis Strips drug can be taken irrespective of food intake. Hours (morning or afternoon) had no clinically significant effect on the rate and extent of absorption.
Tadalafil pharmacokinetics in healthy people is linear with respect to time and dose. In the dose range of 2, 5 and 20 mg of the area under the concentration-time curve (AUC) increases proportionally to dose. Equilibrium plasma concentrations are reached within 5 days, while taking the medicine once a day.
Tadalafil pharmacokinetics in patients with dysfunction of erection is similar to the pharmacokinetics of the drug in patients without violating the duties of an erection.
The mean volume of distribution is around 63 liters, as indicated by the fact that Tadalafil is distributed in body tissues. At therapeutic concentrations of 94% tadalafil in plasma is associated with protein-mi. Protein binding is unchanged in renal failure.
In healthy people under the age of 0, 0005% imposed dose found in the sperm.
Tadalafil is primarily metabolized by the isoenzyme (CYP) 3A4 of cytochrome P450. The main circulating metabolite metilkateholglyukuronid. This metabolite of at least 13,000 times less active against FDE5 of Tadalafil. Therefore, one can hardly assume that the metabolite concentrations was observed, with clinically significant.
In healthy individuals the average clearance tadalafil with ingestion of 2, 5 l / h and the average half-life - 17, 5 hours. Tadalafil appears mostly as inactive metabolites mainly in the faeces (approximately 61% of the dose) and to a lesser extent, with urine (about 36% of the dose).
Healthy elderly (65 years) had a lower clearance with tadalafil ingestion, resulting in increased area under the concentration-time curve by 25% compared to healthy individuals aged 19 to 45 years. This distinction is not clinically significant and does not require the selection of doses.
People with mild (creatinine clearance 51 - 80 ml / min) or intermediate (kreatinina31-clearance 50 ml / min), renal failure, the area under the concentration-time curve was higher than in healthy individuals. People with severe renal impairment (creatinine clearance 30 ml / min) Tadalafil did not study (see "Special warnings and precautions in the application").
Tadalafil pharmacokinetics in patients with little or liver failure compared with healthy individuals. In these patients the selection of the dose is not necessary.
In patients with a history of diabetes tadalafil in an application area under concentration-time curve was 19% lower than that in healthy individuals. This distinction does not require the selection of doses.
Directions:
Cialis Strips shown with erectile dysfunction.
Dosage and Administration:
Cialis Strips inside.
Application Cialis Stripsa middle-aged men
Cialis Stripsa recommended dose is 20 mg. Cialis Strips take before the alleged sexual activity, regardless of the meal. Cialis Strips must be at least 16 minutes before sexual activity.
Patients can attempt sexual activity at any time within 36 hours after admission to establish the optimal Cialis Stripsa response time to receive the drug.
The maximum recommended intake frequency - once a day.
Application Cialis Stripsa in elderly
In elderly patients a special selection of the dose is not necessary. Recommendations for the reception, which is described in the section "Use of middle-aged men" apply to elderly patients.
Cialis Stripsa application in men with renal and hepatic
For patients with renal insufficiency (creatinine clearance 30 mL / min) and liver of a special selection of the dose is not necessary (see "Special warnings and precautions in the application").
Cialis Stripsa application in children
Cialis Strips not apply to persons under 18 years.
Overdose:
With the appointment of a single person to a healthy dose of tadalafil 500 mg and patients with erectile dysfunction - often up to 100 mg / day., Unwanted effects were the same as in the use of lower doses. In case of overdose should be the standard symptomatic treatment.
Contraindications:
# Set tadalafilu or hypersensitivity to any substance, the members of the Cialis Stripsa;
# In the case of products containing any organic nitrates;
# Use of persons under 18 years.
Use during pregnancy and lactation:
Cialis Strips is not intended for use in women.
Side effects:
The most frequently observed side effects were headache and dyspepsia (11 and 7% of cases, respectively). Adverse events associated with tadalafil accommodation often small or medium level of expressiveness, transient and declined with continued use of drugs.
Other common side effects are pain in the back, mialgiya established by the nose and the "bosses" of the blood-to-face.
Rarely - swelling of eyelids, eye pain, conjunctivitis, congestion and dizziness.
Instructions and precautions:
Since there is no evidence of controlled clinical studies on safety and efficacy Cialis Stripsa in the following groups:
# Patients with severe renal impairment (creatinine clearance 30 ml / min)
# Patients with severe hepatic insufficiency, such patients should appoint a drug with caution.
Sexual activity is a potential risk for patients with cardiovascular disease. Therefore, treatment of erectile dysfunction, including the use of Cialis Stripsa, not men with heart disease, in which sexual activity is not recommended.
It should take into account the potential risk of complications of sexual activity in patients with cardiovascular disease:
# Myocardial infarction in the last 90 days;
# Unstable angina, or angina that occurred during sexual intercourse;
# Heart Failure NYHA Class 2 and above, developed over the past 6 months;
# Violations uncontrolled heart rate, hypotension (blood pressure <90/50 mm Hg. St.), or uncontrolled hypertension;
Race # tabled in the last 6 months.
Cialis Strips be used with caution in patients with a predisposition to priapizmu (eg, sickle cell anemia, multiple myeloma or leukemia) or in patients with anatomical deformation of the penis (eg, when the distortion angle, cavernous fibrosis or disease Peyronie).
There are reports of it occurring priapizma using another inhibitor FDE5 - sildenafil, although at a reception Cialis Stripsa any priapizma. Patients should be informed of the need for immediate treatment for medical assistance if an erection continuing 4 hours or more. Late priapizma treatment leads to damage to the penile tissues, which can lead to long-term loss of potency.
Cialis Stripsa safety and efficacy of combination therapy with other types of damage to the functions of erection is not studied. The use of such combinations is not recommended.
Against the backdrop of Cialis Stripsom patients with renal failure secondary to gravity (creatinine clearance 31 -50 mL / min) is more common is an undesirable phenomenon, such as back pain, compared with patients with poorly pronounced renal insufficiency (creatinine clearance 51-80 ml / min) or healthy individuals. In patients with severe renal impairment (creatinine clearance 30 ml / min) Tadalafil has not been studied. Cialis Strips be named with caution to patients with creatinine clearance 50 ml / min.
Drug Interactions:
Effect of other drugs on Cialis Strips (tadalafil):
Tadalafil is metabolized primarily to the involvement of CYP3A4. A selective inhibitor of CYP3A4, ketokonazol increases the area under the concentration-time curve "at 107%, and rifampicin reduced by 88%.
Although the specific interactions are not studied, it can be assumed that like the protease inhibitors ritonavir and saquinavir, as well as inhibitors of CYP3A4 such as erythromycin and itrakonazol increase the activity of tadalafil.
Simultaneous reception of an antacid (aluminum and magnesium hydroxide) and tadalafil reduced the rate of absorption tadalafil without changing the area under the curve tadalafil pharmacokinetics.
The increase in gastric pH as a result of receiving H2-antagonist nizatidina not affect the pharmacokinetics tadalafil.
Influence Cialis Stripsa (tadalafil) on other drugs:
We know that Tadalafil increases the hypotensive effect of nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate). This is due to the additive action of nitrates and tadalafil on the metabolism of nitric oxide and tsGMF. Therefore, the use of Cialis Stripsa in the context of the use of nitrates contraindicated.
Cialis Strips no clinically significant effect on clearance of the drug metabolism of which proceeds with the participation of the cytochrome P450 isoenzyme. Studies have confirmed that Tadalafil is not inhibited and is not induced isoenzyme CYP3A4, CYP1A2, CYP2D6, CYP2E1 and CYP2C9.
Tadalafil has no clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Tadalafil does not affect the effect of warfarin on prothrombin time.
Tadalafil does not increase the duration of bleeding caused by aspirin.
Tadalafil has no clinically significant interactions with major classes of antihypertensive means, including blocking calcium channels (amlodipine), inhibitors of angiotensin converting enzyme (enalapril), beta-adrenergic receptor blockers (metoprolol), alpha-blockers , diuretics tiazidnye (bendoflyuazid) receptor blockers and angiotensin II that were used in different doses as monotherapy or in combination. There were no significant differences in the undesirable events in patients receiving tadalafil in combination with antihypertensive drugs or not.
No influence of acute tadalafil administration on the concentration of alcohol in the blood, the influence of alcohol on cognitive function and blood pressure. Furthermore, no changes in tadalafil concentrations in the blood 3 hours after his admission, in combination with alcohol.
Tadalafil has no clinically significant effect on the pharmacokinetics or pharmacodynamics teofillina.
The impact on the ability to drive and work with the tools:
No special requirements.
Storage conditions:
Store at temperatures below 30 ° C in the original packaging.
Stored in places inaccessible to children.
Shelf life 2 years. Do not use after the date indicated on the packaging.
Terms of the licensing of pharmacies - with a doctor's prescription.
Cialis Strips - information for patients:
What is Cialis Strips?
Cialis Strips - medicines to treat erectile dysfunction. Cialis Strips is a class of enzyme inhibitors fosfodiesterazy-5. Its operation is based on a selective and effective blockade fosfodiesterazy-5, which helps to relax smooth muscle cells and increase blood flow to the penis. Cialis Strips treats erectile dysfunction by increasing blood flow to the penis, with sexual initiation.
Cialis Strips is intended for the treatment of erectile dysfunction of any degree of seriousness. It is recommended for use in internal dose of 20 mg before the alleged sexual activity, regardless of the concomitant ingestion of food or alcohol.
Cialis Strips now - the only fosfodiesterazy-5 inhibitor, the effect that persists longer than a day - up to 36 hours. Importantly, the erection occurs only when sexual initiation. This will help couples do not plan their sexual relationships and not to abandon the normal rhythm of life. Having taken the drug in the morning, take advantage of its effect may be at night.
Cialis Strips is already well established in Europe, Australia and New Zealand. The first countries where the drug has become the United Kingdom, Denmark, Finland, Sweden and Germany.
To date, over 4,000 men have participated in over 60 clinical studies have demonstrated the efficacy and safety of the drug. Cialis Strips improving erectile function in 81% of men and showed a good portability.
Cialis Strips positively influence the following symptoms and consequences of erectile dysfunction:
* Mount a whole;
* The ability to achieve erection sufficient for sexual intercourse;
* Ability to maintain an erection during intercourse;
Get the satisfaction of sexual relationships;
* Positive emotions;
* The satisfaction of a good erection;
* Confidence in the ability to achieve and maintain an erection;
* To meet a sex partner;
* Due to a prolonged effect is Cialis Strips, men now have the option of not constantly thinking about taking the medication.
Cialis Stripsa Why?
Cialis Strips is a high efficiency, which not only improves the erection but also helps the patient regain the naturalness of sexual relations. Cialis Strips is reliable, efficient, easy to use and safe, which restores a normal sexual life of patients suffering from erectile dysfunction, the release of the constant thoughts about treatment.
For a given number of patients clinical effect starts within 16 minutes. Cialis Stripsa after administration and lasts 36 hours.
Cialis Strips, which are in keeping with the need to once daily, improved erectile function in most men suffering from erectile dysfunction of any degree.
What are methods of treating erectile dysfunction are more common?
There are several methods. Oral medications, injections penialnye, erector vacuum implants can help with erectile dysfunction. Sexual or psychological counseling may be useful in the type of psychogenic erectile dysfunction.
If the patient severe erectile dysfunction, may help Cialis Strips?
Yes, clinical trials, 81% of patients receiving 20 mg tablets Cialis Strips showed improvement power. The study included patients with varying degrees of erectile dysfunction, low to severe.
Cialis Strips can help patients suffering from diabetes?
Yes, clinical trials 68% of men with diabetes who Cialis Strips tablets of 20 mg observed improvement in erection.
Andalusia take Cialis Strips?
Patients should take Cialis Strips as prescribed by a doctor or counselor. The drug takes effect within 30 minutes and remains effective up to 36 hours. Cialis Strips can take, regardless of the meal. The result of sexual arousal.
What side effects can be expected from Cialis Stripsa?
Patients receiving any form of organic nitrates should not take Cialis Strips or any other inhibitor FDE5. This combination can cause a dangerous drop in blood pressure. If a patient during the sexual act complained of chest pain or other symptoms related to heart, you should immediately consult a doctor. In clinical trials the most common side effects were headache, indigestion, back pain, muscle and flush-to-face. In general, side effects are weak or moderate, and are rapidly decreasing at a frequency of drug use. In clinical studies, most men do not suffer serious side effects that would lead them to stop Cialis Strips.
Cialis Strips can if you take nitrates?
The patients did not receive any kind of nitrates should not take Cialis Strips. If the patient takes any Cialis Strips taking nitrate drugs, blood pressure can drop to dangerous levels. Many drugs for treatment for pain in the sternum, caused by heart disease contain nitrates. These medicines include nitroglycerin (sprays, ointments, patches or pastes, and tablets under the tongue rassasyvaniya) or isosorbide mononitrate and dinitrate (pills to swallow, chew, or maintained under the tongue). Certain drugs such as amyl nitrate lungs also contain nitrates. This list is not complete, so it is important to know that you are taking nitrates or preparations containing them.
If you have any restriction in the treatment of Cialis Stripsom eat?
No. Cialis Strips may take in connection with or without food.
The best way to take Cialis Strips?
Some men Cialis Strips starts after 16 minutes. For most patients this time is 30 minutes. But remember, without the effect of sexual initiation does not occur. Most patients are Cialis Strips order to be prepared for intimacy with a partner at any convenient time within 36 hours. The recommended maximum duration of one tablet of 20 mg per day.
Can I use Cialis Strips daily for a long time?
Daily use of medication is not recommended.
Patients who suffer an erection when you do not want?
No, Cialis Stripsa necessary for effective sexual arousal.
Cialis Strips act if it is only half a pill?
Cialis Strips is designed for use in doses of 20 mg in divided doses can not be.
Can women take Cialis Strips?
No. Cialis Strips is only for men.
Cialis Strips - medicines to treat erectile dysfunction (Erectile Dysfunction). This is the relaxation of penile arteries and increases blood flow to the penile tissues, and resulting in an erection.
Latin name:
Cialis Strips / Cialis.
The composition and manner of publication:
Cialis Strips coated tablets, 1, 2, 4 or 8 pieces. in the package.
1 tablet contains 20 mg tadalafil Cialis Strips.
Active-active agent:
Tadalafil / Tadalafil.
Properties / Action:
Cialis Strips (tadalafil) is an effective, reversible, selective inhibitor of certain fosfodiesterazy type 5 (FDE5) guanozin cyclic monophosphate (tsGMF). When sexual excitation causes local release of nitric oxide, inhibition FDE5 tadalafilom leads to higher levels tsGMF in the corpus cavernosum of the penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis causing an erection. Tadalafil has no effect in the absence of sexual stimulation.
In vitro studies have shown that tadalafil is a selective inhibitor FDE5. FDE5 an enzyme that is found in smooth muscles of cavernous bodies in vascular smooth muscles of internal organs, skeletal muscle, platelets, kidney, lung, and cerebellum. Step FDE5 to tadalafil is more active than the other fosfodiesterazy. Tadalafil is 10 000 times more potent against FDE5 that FDE1, FDE2 and FDE4, which located in the heart, brain, blood vessels, liver and other organs. Tadalafil 10 000 times more blocks FDE5 that FDE3 - enzyme which is located in the heart and blood vessels. This selectivity in comparison with FDE5 against Fdez Fdez is important because an enzyme involved in the reduction of the heart muscle. In addition, tadalafil approximately 700 times more active against FDE5 that FDE6 found in the retina and is responsible for fotoperedachu. Tadalafil is 10 000 times more potent against FDE5 compared with its impact on FDE7 - FDE10.
Tadalafil improves erection and the possibility of a satisfying sexual relationship. The drug is valid for 36 hours. The effect is manifested after 16 minutes after taking the drug in the presence of sexual arousal.
Tadalafil in healthy individuals is a reliable change systolic and diastolic pressures compared with placebo in the prone position (mean maximum decrease of 1, 6 / 0, 8 mm Hg. Art, respectively) and standing (maximum mean decrease of 0 , 2 / 4, 6 mm Hg. art., respectively). Tadalafil does not cause a reliable change in heart rate.
Tadalafil does not cause changes in the recognition of colors (blue / green), due to its low affinity FDEb. In addition, tadalafil no influence on visual acuity, elektroretinogrammu, intraocular pressure and pupil size.
Tadalafil study in men in a daily dose of 10 mg showed no clinically significant effect on the quantity of drugs and sperm concentration, motility and morphology of spermatozoa.
Pharmacokinetics:
After receiving tadalafil Cialis Stripsa interior absorbs quickly. The average maximum concentration (smax) in plasma is reached after an average of 2 hours after ingestion.
The rate and extent of tadalafil absorption is not dependent on food intake, so Cialis Strips drug can be taken irrespective of food intake. Hours (morning or afternoon) had no clinically significant effect on the rate and extent of absorption.
Tadalafil pharmacokinetics in healthy people is linear with respect to time and dose. In the dose range of 2, 5 and 20 mg of the area under the concentration-time curve (AUC) increases proportionally to dose. Equilibrium plasma concentrations are reached within 5 days, while taking the medicine once a day.
Tadalafil pharmacokinetics in patients with dysfunction of erection is similar to the pharmacokinetics of the drug in patients without violating the duties of an erection.
The mean volume of distribution is around 63 liters, as indicated by the fact that Tadalafil is distributed in body tissues. At therapeutic concentrations of 94% tadalafil in plasma is associated with protein-mi. Protein binding is unchanged in renal failure.
In healthy people under the age of 0, 0005% imposed dose found in the sperm.
Tadalafil is primarily metabolized by the isoenzyme (CYP) 3A4 of cytochrome P450. The main circulating metabolite metilkateholglyukuronid. This metabolite of at least 13,000 times less active against FDE5 of Tadalafil. Therefore, one can hardly assume that the metabolite concentrations was observed, with clinically significant.
In healthy individuals the average clearance tadalafil with ingestion of 2, 5 l / h and the average half-life - 17, 5 hours. Tadalafil appears mostly as inactive metabolites mainly in the faeces (approximately 61% of the dose) and to a lesser extent, with urine (about 36% of the dose).
Healthy elderly (65 years) had a lower clearance with tadalafil ingestion, resulting in increased area under the concentration-time curve by 25% compared to healthy individuals aged 19 to 45 years. This distinction is not clinically significant and does not require the selection of doses.
People with mild (creatinine clearance 51 - 80 ml / min) or intermediate (kreatinina31-clearance 50 ml / min), renal failure, the area under the concentration-time curve was higher than in healthy individuals. People with severe renal impairment (creatinine clearance 30 ml / min) Tadalafil did not study (see "Special warnings and precautions in the application").
Tadalafil pharmacokinetics in patients with little or liver failure compared with healthy individuals. In these patients the selection of the dose is not necessary.
In patients with a history of diabetes tadalafil in an application area under concentration-time curve was 19% lower than that in healthy individuals. This distinction does not require the selection of doses.
Directions:
Cialis Strips shown with erectile dysfunction.
Dosage and Administration:
Cialis Strips inside.
Application Cialis Stripsa middle-aged men
Cialis Stripsa recommended dose is 20 mg. Cialis Strips take before the alleged sexual activity, regardless of the meal. Cialis Strips must be at least 16 minutes before sexual activity.
Patients can attempt sexual activity at any time within 36 hours after admission to establish the optimal Cialis Stripsa response time to receive the drug.
The maximum recommended intake frequency - once a day.
Application Cialis Stripsa in elderly
In elderly patients a special selection of the dose is not necessary. Recommendations for the reception, which is described in the section "Use of middle-aged men" apply to elderly patients.
Cialis Stripsa application in men with renal and hepatic
For patients with renal insufficiency (creatinine clearance 30 mL / min) and liver of a special selection of the dose is not necessary (see "Special warnings and precautions in the application").
Cialis Stripsa application in children
Cialis Strips not apply to persons under 18 years.
Overdose:
With the appointment of a single person to a healthy dose of tadalafil 500 mg and patients with erectile dysfunction - often up to 100 mg / day., Unwanted effects were the same as in the use of lower doses. In case of overdose should be the standard symptomatic treatment.
Contraindications:
# Set tadalafilu or hypersensitivity to any substance, the members of the Cialis Stripsa;
# In the case of products containing any organic nitrates;
# Use of persons under 18 years.
Use during pregnancy and lactation:
Cialis Strips is not intended for use in women.
Side effects:
The most frequently observed side effects were headache and dyspepsia (11 and 7% of cases, respectively). Adverse events associated with tadalafil accommodation often small or medium level of expressiveness, transient and declined with continued use of drugs.
Other common side effects are pain in the back, mialgiya established by the nose and the "bosses" of the blood-to-face.
Rarely - swelling of eyelids, eye pain, conjunctivitis, congestion and dizziness.
Instructions and precautions:
Since there is no evidence of controlled clinical studies on safety and efficacy Cialis Stripsa in the following groups:
# Patients with severe renal impairment (creatinine clearance 30 ml / min)
# Patients with severe hepatic insufficiency, such patients should appoint a drug with caution.
Sexual activity is a potential risk for patients with cardiovascular disease. Therefore, treatment of erectile dysfunction, including the use of Cialis Stripsa, not men with heart disease, in which sexual activity is not recommended.
It should take into account the potential risk of complications of sexual activity in patients with cardiovascular disease:
# Myocardial infarction in the last 90 days;
# Unstable angina, or angina that occurred during sexual intercourse;
# Heart Failure NYHA Class 2 and above, developed over the past 6 months;
# Violations uncontrolled heart rate, hypotension (blood pressure <90/50 mm Hg. St.), or uncontrolled hypertension;
Race # tabled in the last 6 months.
Cialis Strips be used with caution in patients with a predisposition to priapizmu (eg, sickle cell anemia, multiple myeloma or leukemia) or in patients with anatomical deformation of the penis (eg, when the distortion angle, cavernous fibrosis or disease Peyronie).
There are reports of it occurring priapizma using another inhibitor FDE5 - sildenafil, although at a reception Cialis Stripsa any priapizma. Patients should be informed of the need for immediate treatment for medical assistance if an erection continuing 4 hours or more. Late priapizma treatment leads to damage to the penile tissues, which can lead to long-term loss of potency.
Cialis Stripsa safety and efficacy of combination therapy with other types of damage to the functions of erection is not studied. The use of such combinations is not recommended.
Against the backdrop of Cialis Stripsom patients with renal failure secondary to gravity (creatinine clearance 31 -50 mL / min) is more common is an undesirable phenomenon, such as back pain, compared with patients with poorly pronounced renal insufficiency (creatinine clearance 51-80 ml / min) or healthy individuals. In patients with severe renal impairment (creatinine clearance 30 ml / min) Tadalafil has not been studied. Cialis Strips be named with caution to patients with creatinine clearance 50 ml / min.
Drug Interactions:
Effect of other drugs on Cialis Strips (tadalafil):
Tadalafil is metabolized primarily to the involvement of CYP3A4. A selective inhibitor of CYP3A4, ketokonazol increases the area under the concentration-time curve "at 107%, and rifampicin reduced by 88%.
Although the specific interactions are not studied, it can be assumed that like the protease inhibitors ritonavir and saquinavir, as well as inhibitors of CYP3A4 such as erythromycin and itrakonazol increase the activity of tadalafil.
Simultaneous reception of an antacid (aluminum and magnesium hydroxide) and tadalafil reduced the rate of absorption tadalafil without changing the area under the curve tadalafil pharmacokinetics.
The increase in gastric pH as a result of receiving H2-antagonist nizatidina not affect the pharmacokinetics tadalafil.
Influence Cialis Stripsa (tadalafil) on other drugs:
We know that Tadalafil increases the hypotensive effect of nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate). This is due to the additive action of nitrates and tadalafil on the metabolism of nitric oxide and tsGMF. Therefore, the use of Cialis Stripsa in the context of the use of nitrates contraindicated.
Cialis Strips no clinically significant effect on clearance of the drug metabolism of which proceeds with the participation of the cytochrome P450 isoenzyme. Studies have confirmed that Tadalafil is not inhibited and is not induced isoenzyme CYP3A4, CYP1A2, CYP2D6, CYP2E1 and CYP2C9.
Tadalafil has no clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Tadalafil does not affect the effect of warfarin on prothrombin time.
Tadalafil does not increase the duration of bleeding caused by aspirin.
Tadalafil has no clinically significant interactions with major classes of antihypertensive means, including blocking calcium channels (amlodipine), inhibitors of angiotensin converting enzyme (enalapril), beta-adrenergic receptor blockers (metoprolol), alpha-blockers , diuretics tiazidnye (bendoflyuazid) receptor blockers and angiotensin II that were used in different doses as monotherapy or in combination. There were no significant differences in the undesirable events in patients receiving tadalafil in combination with antihypertensive drugs or not.
No influence of acute tadalafil administration on the concentration of alcohol in the blood, the influence of alcohol on cognitive function and blood pressure. Furthermore, no changes in tadalafil concentrations in the blood 3 hours after his admission, in combination with alcohol.
Tadalafil has no clinically significant effect on the pharmacokinetics or pharmacodynamics teofillina.
The impact on the ability to drive and work with the tools:
No special requirements.
Storage conditions:
Store at temperatures below 30 ° C in the original packaging.
Stored in places inaccessible to children.
Shelf life 2 years. Do not use after the date indicated on the packaging.
Terms of the licensing of pharmacies - with a doctor's prescription.
Cialis Strips - information for patients:
What is Cialis Strips?
Cialis Strips - medicines to treat erectile dysfunction. Cialis Strips is a class of enzyme inhibitors fosfodiesterazy-5. Its operation is based on a selective and effective blockade fosfodiesterazy-5, which helps to relax smooth muscle cells and increase blood flow to the penis. Cialis Strips treats erectile dysfunction by increasing blood flow to the penis, with sexual initiation.
Cialis Strips is intended for the treatment of erectile dysfunction of any degree of seriousness. It is recommended for use in internal dose of 20 mg before the alleged sexual activity, regardless of the concomitant ingestion of food or alcohol.
Cialis Strips now - the only fosfodiesterazy-5 inhibitor, the effect that persists longer than a day - up to 36 hours. Importantly, the erection occurs only when sexual initiation. This will help couples do not plan their sexual relationships and not to abandon the normal rhythm of life. Having taken the drug in the morning, take advantage of its effect may be at night.
Cialis Strips is already well established in Europe, Australia and New Zealand. The first countries where the drug has become the United Kingdom, Denmark, Finland, Sweden and Germany.
To date, over 4,000 men have participated in over 60 clinical studies have demonstrated the efficacy and safety of the drug. Cialis Strips improving erectile function in 81% of men and showed a good portability.
Cialis Strips positively influence the following symptoms and consequences of erectile dysfunction:
* Mount a whole;
* The ability to achieve erection sufficient for sexual intercourse;
* Ability to maintain an erection during intercourse;
Get the satisfaction of sexual relationships;
* Positive emotions;
* The satisfaction of a good erection;
* Confidence in the ability to achieve and maintain an erection;
* To meet a sex partner;
* Due to a prolonged effect is Cialis Strips, men now have the option of not constantly thinking about taking the medication.
Cialis Stripsa Why?
Cialis Strips is a high efficiency, which not only improves the erection but also helps the patient regain the naturalness of sexual relations. Cialis Strips is reliable, efficient, easy to use and safe, which restores a normal sexual life of patients suffering from erectile dysfunction, the release of the constant thoughts about treatment.
For a given number of patients clinical effect starts within 16 minutes. Cialis Stripsa after administration and lasts 36 hours.
Cialis Strips, which are in keeping with the need to once daily, improved erectile function in most men suffering from erectile dysfunction of any degree.
What are methods of treating erectile dysfunction are more common?
There are several methods. Oral medications, injections penialnye, erector vacuum implants can help with erectile dysfunction. Sexual or psychological counseling may be useful in the type of psychogenic erectile dysfunction.
If the patient severe erectile dysfunction, may help Cialis Strips?
Yes, clinical trials, 81% of patients receiving 20 mg tablets Cialis Strips showed improvement power. The study included patients with varying degrees of erectile dysfunction, low to severe.
Cialis Strips can help patients suffering from diabetes?
Yes, clinical trials 68% of men with diabetes who Cialis Strips tablets of 20 mg observed improvement in erection.
Andalusia take Cialis Strips?
Patients should take Cialis Strips as prescribed by a doctor or counselor. The drug takes effect within 30 minutes and remains effective up to 36 hours. Cialis Strips can take, regardless of the meal. The result of sexual arousal.
What side effects can be expected from Cialis Stripsa?
Patients receiving any form of organic nitrates should not take Cialis Strips or any other inhibitor FDE5. This combination can cause a dangerous drop in blood pressure. If a patient during the sexual act complained of chest pain or other symptoms related to heart, you should immediately consult a doctor. In clinical trials the most common side effects were headache, indigestion, back pain, muscle and flush-to-face. In general, side effects are weak or moderate, and are rapidly decreasing at a frequency of drug use. In clinical studies, most men do not suffer serious side effects that would lead them to stop Cialis Strips.
Cialis Strips can if you take nitrates?
The patients did not receive any kind of nitrates should not take Cialis Strips. If the patient takes any Cialis Strips taking nitrate drugs, blood pressure can drop to dangerous levels. Many drugs for treatment for pain in the sternum, caused by heart disease contain nitrates. These medicines include nitroglycerin (sprays, ointments, patches or pastes, and tablets under the tongue rassasyvaniya) or isosorbide mononitrate and dinitrate (pills to swallow, chew, or maintained under the tongue). Certain drugs such as amyl nitrate lungs also contain nitrates. This list is not complete, so it is important to know that you are taking nitrates or preparations containing them.
If you have any restriction in the treatment of Cialis Stripsom eat?
No. Cialis Strips may take in connection with or without food.
The best way to take Cialis Strips?
Some men Cialis Strips starts after 16 minutes. For most patients this time is 30 minutes. But remember, without the effect of sexual initiation does not occur. Most patients are Cialis Strips order to be prepared for intimacy with a partner at any convenient time within 36 hours. The recommended maximum duration of one tablet of 20 mg per day.
Can I use Cialis Strips daily for a long time?
Daily use of medication is not recommended.
Patients who suffer an erection when you do not want?
No, Cialis Stripsa necessary for effective sexual arousal.
Cialis Strips act if it is only half a pill?
Cialis Strips is designed for use in doses of 20 mg in divided doses can not be.
Can women take Cialis Strips?
No. Cialis Strips is only for men.
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